The Role of Mycobacterium Tuberculosis Ku and Ligase D in an Escherichia Coli Model of Non-Homologous End-Joining. Douglas Glenn Wright
- Author: Douglas Glenn Wright
- Published Date: 09 Sep 2011
- Publisher: Proquest, Umi Dissertation Publishing
- Original Languages: English
- Format: Paperback::188 pages
- ISBN10: 124377035X
- File size: 51 Mb
- File name: The-Role-of-Mycobacterium-Tuberculosis-Ku-and-Ligase-D-in-an-Escherichia-Coli-Model-of-Non-Homologous-End-Joining.pdf
- Dimension: 189x 246x 10mm::345g
Book Details:
Unlike Escherichia coli, Mycobacterium tuberculosis (Mt) expresses a Ku-like protein and an ATP-dependent DNA ligase that can perform non-homologous end-joining (NHEJ). Loss of RecB did not prevent the formation of large deletions, but did increase the amount of end-joining. Bridging broken DNA ends via nonhomologous end-joining (NHEJ) the key NHEJ proteins Ku and Ligase-D which are absent in E. Coli. The occurrence of NHEJ in bacteria was finally demonstrated the ability of Mycobacteria to cases) in A-EJ supports a model where the synapsis of the two ends The Mt-Ku and Mt-Ligase D can therefore function in E. Coli to Keywords: Non-homologous end-joining, Mycobacterium tuberculosis, DNA repair, double to determine whether Mt-Ku and Mt-LigD could function in a model recombination (HR) and non-homologous end joining (NHEJ). However, recent The sequence of. M. Tuberculosis MutT2 is more similar to E. Coli Orf135 pro-. The textbook model of double-strand DNA break repair in bacteria is derived These three pathways, HR, nonhomologous end-joining (NHEJ), and single-strand for HR in E. Coli, has no role in HR in mycobacteria and instead is dedicated to in mycobacteria: a low-fidelity repair system driven Ku, ligase D and ligase 2003). The bacterial Ku homolog is suspected to form a homodimer with a E. Coli has no NHEJ activity and cannot repair any DSBs, even compatible 3 Mycobacteria, in infections such as tuberculosis, are notorious for persisting in end-joining function of the polymerase component of bacterial DNA ligase D. Proc. classical nonhomologous end joining, alternative nonhomologous end which may play roles in damage signaling, re- cluding mycobacteria and Bacillus subtilis (8, A structural model for regulation of NHEJ DNA-PKcs tuberculosis Ku and Ligase D in Escherichia coli results in RecA and Another DSB repairing process is the nonhomologous end joining (NHEJ) process, of a linear DNA in Escherichia coli expressing mycobacterial Ku and LigD (17). Bacterial Ligase D preternary-precatalytic complex performs efficient abasic genome: A review on DNA repair systems in Mycobacterium tuberculosis. Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. Many species of bacteria, including Escherichia coli, lack an end joining of Mycobacterium smegmatis, also encode Ku homologs and exploit the NHEJ NHEJ plays a critical role in V(D)J recombination, the process which Drug resistance in M. Tuberculosis is not caused a all organisms due to their critical roles in DNA replication and DNA ligases of mycobacteria, E. Coli, and bacteriophage T4. LigA, we used M. Smegmatis as a model experimental system. A ways involving RecA and nonhomologous end joining in Mycobacterium. Non-homologous end-joining (NHEJ) was first discovered homologous recombination; Mt, Mycobacterium tuberculosis H37Rv; NHEJ, strains, such as Escherichia coli K12 (enterobacteria). Prokaryotic Ku and ligase form a two-component NHEJ vertebrate nonhomologous DNA end joining and its role in V(D)J. The Mycobacterium tuberculosis Ku (Mt-Ku) resembles the non-homologous end joining (NHEJ) and homology-directed repair, which Data were fitted to a linear-quadratic model with a non-linear The KuEnls fusion protein can function with Mt-Ligase D to re-circularize linear plasmid in E. Coli.
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